Hunan's Best — Inventions and Major Achievements (Part 2)
Patented Products, Industry Leader: Hunan's pioneering method for static spawning of domestic fish—artificial induction of grass carp spawning. In 1958, Professor Liu Yun of Hunan Normal University's Biology Department confirmed through field observation that pond-raised domestic fish could develop germ cells normally, but female oocytes could only develop to the primary oocyte stage.
This article has been compiled from historical materials in the "Zhangjiajie Tour Guide Network" (33519.com · City Overview section). Some administrative divisions, population, socioeconomic data, and policy information may be outdated and are for reference only; for the latest situation, please refer to official releases by the local government and scenic areas.
Section II
Patented Products, Industry Leader
Hunan's Pioneering Method for Inducing Spawning of Farmed Fish in Still Water—Artificial Hormone Induction of Grass Carp
In 1958, Professor Liu Yun of the Biology Department of Hunan Normal College conducted in-depth and meticulous field observations and confirmed that the germ cells of farmed fish grown in ponds could develop normally, but female oocytes could only develop to the primary oocyte stage and required gonadal hormones to mature and ovulate. This discovery provided a scientific basis for artificial induced spawning of farmed fish. The following year, the Provincial Fisheries Bureau and the Biology Department of Hunan Normal College, at Guiyang Commune in Qidong County, for the first time used artificial hormone induction to hatch silver carp fry. The artificial hormone induction of natural spawning in grass carp was a domestic first. This achievement mastered the patterns of gonadal development in brood fish and the external characteristics of mature brood fish; systematically studied the developmental patterns of germ cells and fertilized cells, the principles of artificial induced spawning of farmed fish, and the mechanisms of action of spawning-inducing drugs; for the first time determined the technical route for inducing spawning of farmed fish in still water; and summarized and organized the technical operating procedures for artificial propagation of farmed fish. In 1980, this research won the First Prize for Major Scientific and Technological Achievements of the province.
China's First Exported Agricultural Patent Technology—Heterosis Utilization Technology
In 1964, Comrade Yuan Longping, a teacher at Qianyang Agricultural School in Hunan Province, first discovered a male sterile plant in rice and began research on the three-line system of rice heterosis. Yuan Longping and his assistants spent a full six years, successively using more than 1,000 varieties and making more than 3,000 cross combinations, yet still failed to breed a sterile line with both sterile plant rate and sterility degree reaching 100%. The research group then proposed a new idea of 'crossing distant wild rice with cultivated rice.' On November 23, 1970, in a population of common wild rice on Hainan Island, they discovered a plant with abortive male flowers, and using varieties such as Guangchang'ai and Jingyin 66 for test crosses, found that it had the ability to maintain the wild abortive sterile line, thus opening a breakthrough for breeding rice sterile lines and the subsequent 'three-line' system. In 1973, on the basis of breaking through the 'sterile line' and 'maintainer line,' the vast number of scientific and technical personnel selected more than 1,000 varieties for test-cross screening and found more than 1,000 varieties with restoring ability. Zhang Xiancheng, Yuan Longping, and others were the first to find a group of 'restorer lines' represented by IR24 with strong heterosis, large pollen quantity, and restoration degree above 90%. In October, Yuan Longping published a paper titled 'Progress in Breeding Three Lines Using Wild Abortive Type,' formally announcing the success of the 'three-line' system of indica hybrid rice in China, solving the three-line system of Chinese rice for the first time. This was a major breakthrough in rice breeding in China. On October 20, 1975, indica hybrid rice passed appraisal and began to be promoted on a large scale nationwide. This indica rice heterosis utilization technology became China's first agricultural patent exported to the United States and made major contributions to increasing world grain production.
A World-First Special Technology—High-Yield Hybrid Rice Seed Production Technology
From 1981 to 1983, the Hunan Provincial Seed Company focused systematic research on the reasons for the low panicle grain exsertion rate (neck enclosure) of the wild abortive sterile line, the problem that large-scale seed production at that time required extensive manual leaf cutting, leaf removal, and glume peeling, and the solutions and corresponding high-yield technologies. The research found that the low panicle grain exsertion rate of the wild abortive sterile line was mainly caused by the short internode of the lower panicle neck node, which prevented the panicle grains from fully emerging from the flag leaf sheath. Their research results further showed that on the basis of an ideal flowering period, implementing directional cultivation and a complete set of new high-yield seed production technologies including no leaf cutting, no leaf removal, no glume peeling, and timely, appropriate, and properly applied spraying of GA3 could increase the panicle grain exsertion rate by 32.2% to 54.3%, increase the flag leaf angle and glume opening angle by 10.6 to 66.6 degrees and 1 to 14 degrees respectively, increase the stigma exsertion rate by 5.1% to 43.4%, and increase the outcrossing seed-setting rate by more than 11%. From 1983 to 1986, the province demonstrated and promoted 40,815 hectares, with yield increases reaching 12.5% to 15.6% respectively, and cumulative economic benefits of 190.5433 million yuan, with an average annual investment return rate of 101.4%. Practice proved that this research achievement was a major breakthrough in seed production technology and a world first. This research achievement won the First Prize for Provincial Science and Technology Progress in 1986.
World-Leading Genetic Engineering Rice Breeding Technology—Exogenous DNA Introduction Technology
The world's first successfully bred genetic engineering rice was researched beginning in 1991 by a 14-member genetic engineering rice research group at Hunan Agricultural University including Wan Wenju, Zou Dongsheng, Zhang Fuquan, Peng Keqin, and Dong Yanyu, and was listed as a provincial key research project the following year. Genetic engineering rice is a new rice line, abbreviated GER, developed by introducing maize DNA into rice using the exogenous DNA solution embryo soaking method and then through multi-generation directional selection from variant progeny. In basic research, through electron microscopy observation, DNA molecular detection, chromosome G-banding analysis, and isozyme analysis, it was preliminarily found that GER-1 had acquired some maize DNA fragments (genes) and had stably inherited them, exhibiting certain characteristics and traits similar to maize, confirming that the exogenous DNA embryo soaking method is a feasible new breeding approach. Research on the mechanism of high-yield formation also preliminarily established that GER-1 has high photosynthetic efficiency, sufficient material production sources, large sink capacity, smooth material transport, and reasonable distribution. In October 1993, GER-1 passed technical appraisal chaired by the Hunan Provincial Science and Technology Commission. Eighteen renowned experts and scholars from within and outside the province unanimously agreed that the development of GER-1 was a major achievement in the application of exogenous DNA introduction technology to rice breeding and was at the international leading level.
China's First Aromatic Sterile Line—Hybrid Aromatic Rice Combination
Research on indica hybrid aromatic rice sterile lines and their strong heterotic combinations began in 1984 and was later included in the provincial 'Seventh Five-Year Plan' key project 'Breeding of New High-Yield, High-Quality, Multi-Resistant Hybrid Rice Combinations' and the provincial 'Eighth Five-Year Plan' key project 'Breeding of New Commercial High-Quality Rice Varieties (Combinations),' chaired by Zhou Kunlu of the Hunan Hybrid Rice Research Center, with Yang Hehua and others participating. In September 1994, the Provincial Science and Technology Commission organized experts from within and outside the province for technical appraisal. The experts believed that Xinxiang A had moderate plant and leaf traits, uniform growth, and good agronomic traits. Its pollen abortion degree was above 99.8%, and both the sterile plant rate and sterile pollen rate were 100%, fully meeting the sterility requirements of three-line sterile lines. It had good restorability, a broad restoration spectrum, and obvious heterosis. It had good combining ability, a relatively high outcrossing seed-setting rate, and excellent grain quality. It was China's first aromatic sterile line, resolving the long-standing contradiction between high yield and high quality in hybrid rice. This achievement was at the leading level among similar domestic research.
China's First Newly Discovered Rice Pathogenic Variety—Rice Brown Sheath Disease
The incidence of rice brown sheath disease in southern rice regions was 20-50% in previous years, reaching 90% in severe areas. Chen Luokuan, Liao Xiaolan, Shan Wenzhou, and others from the Plant Protection Research Laboratory Plant Disease Group of Hunan Agricultural College, the Plant Protection Group of Hengyang Agricultural Science Institute, and the Changde Branch of Hunan Agricultural College began researching this disease in 1984. In conducting the research, they used a combination of classical conventional and molecular biological techniques to identify the brown sheath pathogen bacterium as a new pathogenic variety not previously reported domestically or internationally, ruling out the possibility of mites, fungi, and viruses. At the same time, they confirmed that diseased seeds, diseased straw, mites, and the roots of Polypogon fugax could carry and transmit the disease. The disease began to occur at the full heading stage, peaked from the milk-ripe to dough-ripe stages, and was closely related to varietal resistance during the growth period, with heavy disease occurring under high nitrogen fertilizer. Control should focus on promoting disease-resistant varieties as the main comprehensive measure, and a batch of highly resistant resistance source materials was identified. In November 1988, the technical appraisal organized by the Provincial Education Commission held that the new discovery of brown sheath disease was highly scientific, practical, and academically valuable, and was at the domestic leading level. The achievement was promoted on a large scale beginning in 1989 and won the Second Prize for Provincial Science and Technology Progress in 1990.
Hunan's Pioneering Pond Aquaculture Artificial Spawning Technology—Artificial Propagation Technology for Plagiognathops microlepis
In July 1993, Li Daoming, Luo Shaohai, Liao Xiulan and others from the Wuling District Animal Husbandry and Aquatic Products Bureau conducted technical experiments on artificial breeding using diethylstilbestrol plus luteinizing hormone-releasing hormone analogs, inducing 4.09 million fish fry, and won the third prize of the Ministry of Agriculture's "Pond Model Aquaculture Yield Increase Technology" harvest project. The artificial breeding technology for the fine-scaled oblique-jawed xenocypris adopted advanced artificial induction techniques, pioneering the artificial induction of the fine-scaled oblique-jawed xenocypris using diethylstilbestrol to promote community-releasing hormone analogs, and found an ideal drug that can replace the pituitary for artificial induction of the fine-scaled oblique-jawed xenocypris, with broad value for promotion and application. At the same time, it provided an effective solution to the difficulty faced by aquaculture production units nationwide in obtaining large quantities of fry and fingerlings for raising high-quality fine-scaled oblique-jawed xenocypris, and was truly a first in the province, the nation, and even the world.
China's first technology for preventing and treating explosive fish diseases in large and medium-sized waters — application of quicklime
From 2000 to 2001, scientific and technical personnel from the Linli County Water Conservancy Bureau and the Linli County Guanting Reservoir Management Office closely combined with production practice and boldly explored, applying quicklime on a large scale, in heavy doses, and in a timely and scientific manner for the first time in 6,000 mu of large water surface, fundamentally bringing the explosive fish disease under control in a short period and achieving good economic, social, and ecological benefits. This technology successfully solved the technical problem of preventing and treating explosive fish diseases in large and medium-sized waters in China and blazed a new path. The county's pioneering technology for preventing explosive fish diseases had not been reported anywhere else in the country. In December 2001, the Provincial Department of Science and Technology organized experts for appraisal, and the technical level was deemed a first in the province and at the advanced national level, and should be vigorously promoted. In September 2002, the paper summarizing this technology, "Research on Technology for Preventing and Treating Explosive Fish Diseases in Large and Medium-sized Waters," was published in the national core aquatic journal Water Conservancy and Fisheries.
China's first river hydropower station hub-type fishway — Yangtang Fishway
Yangtang Fishway is located on the left side of the Yangtang Water Turbine Pump Hydropower Station in Hengdong County, downstream of the Zhushui River, a major tributary of the Xiangjiang River. After the Yangtang River dam was completed, its migratory passage was cut off. From 1976 to 1980, the Hengdong County Water Conservancy and Electric Power Bureau, the Hengdong County Yangtang Water Turbine Pump Hydropower Station, and Lin Qinhao, Yang Juying, Wang Zhensheng, Xiang Hengxun and others from the Nanjing Hydraulic Research Institute researched and designed, and built here China's first river hydropower station hub-type fishway with a powerhouse fish-collecting system. After more than two months of operation and observation, 45 species and more than 500,000 fish passed through the fishway, with individual lengths of 10–110 cm, and an average of 385 fish passing per hour during the spawning season, setting the highest domestic record for both species and quantity passing through. In April 1984, the Aquatic Products Bureau of the Ministry of Agriculture, Animal Husbandry and Fisheries entrusted the Provincial Aquatic Products Bureau with appraising this achievement, which won the third prize of the 1980 Provincial Major Scientific and Technological Achievement Award.
China's first pearl cultivation technology in mountainous waters — three major pearl cultivation achievements
In order to prevent the spread of triangular sail mussel plague in the lake area and protect China's unique shellfish pearl mussel resource, Zhang Yuanpei, Jia Shixiang, Yan Qinghua, Long Huizhen, Bian Wei and others from the Provincial Institute of Aquatic Science and the Shimen County Animal Husbandry and Aquatic Products Bureau completed research from 1990 to 1992 on cultivating high-quality pearls in mountainous waters and achieved important results. First, in the technology for cultivating fine-li non-nucleated pearls, they used cell-free body staining technology to cultivate fine-li pearls; in the technology for cultivating spherical night-luminous pearls, they used zinc sulfide as the fluorescent body and copper or mercury as the activator to prepare the night-luminous pearl matrix nucleus. Testing showed that the radioactivity intensity of the night-luminous pearls cultivated by this technology met radiation health standards. In the technology for cultivating pictographic night-luminous pearls, based on the above principles for cultivating night-luminous pearls, through research and experimentation they successfully cultivated shape-controlled pictographic night-luminous pearls. In November 1992, experts from pearl production areas in multiple provinces and cities appraised: the above three achievements were all firsts in China, their technical level was leading domestically and had reached the international advanced level.
World-leading ramie cultivation technology — ramie flower control technology
Ramie is an excellent fiber raw material for the textile industry. It is harvested three times each year. The first and second harvests have better quality, while the third harvest has poorer quality and lower yield. In order to improve the quality and increase the yield of the third harvest, starting in 1988, the Yuanjiang Plant Growth Regulation Technology Research Institute, the Shenyang Research Institute of Chemical Industry of the Ministry of Chemical Industry, and the Science and Technology Station of the Dongnanhu Reed Farm in Yuanjiang City jointly carried out research on ramie flower control technology. In 1989 it was included in the Yuanjiang City Science and Technology Commission research plan, and in 1990 it was listed as a key provincial research topic in Hunan. Under the guidance of senior engineers Chen Hubao and Zhu Huixiang, through formulation and screening of agents and determination of the optimal application time and concentration, from small-plot trials to large-area demonstrations, and after isotope P32 tracing tests by the Shanghai Institute of Plant Physiology of the Chinese Academy of Sciences and physiological and morphological measurements by the Biology Department of Hebei Normal University, the ramie flower control technology achieved a breakthrough in Yuanjiang in September 1991. In April 1992, the Hunan Provincial Science and Technology Commission presided over the appraisal, and peer experts unanimously agreed: this research was at the world-leading level, had great significance for production practice and high academic value, and should be recommended for promotion and application nationwide.
China's first brick tea production process innovation — new process for Fu brick tea production
The new process for Fu brick tea production was proposed and successfully developed by Peng Gao of the Linxiang City Agriculture Bureau in Hunan Province, targeting the shortcomings of the traditional Fu brick tea production process. Linxiang is one of China's top ten tea-producing counties (cities), and Fu brick tea production has a history of more than 300 years, but the traditional production process was outdated and backward, with a long production cycle, high cost, and heavy labor. Targeting these shortcomings, Peng Gao conducted transformation experiments on the traditional production process at the Linxiang City Tea Factory, and after five years of effort successfully developed the new process for Fu brick tea production. In October 1994, the Yueyang City Science and Technology Commission organized senior agronomists, professors, and researchers from the Hunan Provincial Department of Agriculture, Hunan Agricultural University, and the Provincial Tea Research Institute to appraise it, concluding: "This process was proposed for the first time in China, and no relevant reports have been seen abroad either; it is truly a process innovation."
Hunan's first male-sterile and sac-abortive ponkan line — Qianyang seedless ponkan
Qianyang seedless ponkan is a new bud-sport variety selected by agricultural science and technology personnel in Hunan Province from ordinary ponkan. In 1999, the Citrus and Seedling Quality Supervision, Inspection and Testing Center of the Ministry of Agriculture recognized it as having "extremely excellent quality" and awarded it the title of "High-Quality Fruit." In the same year, at the National Citrus Variety Structure Adjustment Strategy Seminar and Special Excellent New Variety Exhibition, it was rated as a recommended variety for citrus variety structure adjustment and included in the National Spark Program and the National Agricultural Science and Technology Achievement Promotion Plan. After genetic trait identification by the Hunan Horticultural Research Institute, this variety was confirmed as China's first case of male sterility and sac abortion, with stable seedless fruit.
Section Three
Medical science and technology, good news for doctors and patients
China's first multidisciplinary comprehensive study of an ancient corpse — study of the Western Han female corpse unearthed at Mawangdui, Changsha
From 1972 to 1974, the former Hunan Medical University, the Provincial Institute of Traditional Chinese Medicine, the laboratory of the Provincial Bureau of Geology and Mineral Resources, the Provincial Museum, and the Hunan Pharmaceutical Industry Research Institute, with the cooperation of relevant departments and research units of the state and Beijing, Shanghai, and other places, closely integrated medicine and archaeology and completed a multidisciplinary comprehensive study of the Western Han female corpse unearthed at Mawangdui in Changsha. In-depth research was carried out in three aspects: study of the degree of preservation and anti-corrosion treatment of the ancient corpse, pathological anatomy, and the reasons why the female corpse had not decayed for so long, yielding abundant research results and reaching unprecedented breadth and depth at home and abroad, providing valuable experience for the excavation and protection of unearthed cultural relics and for planned research on ancient corpses. This research achievement won the 1978 National Science Conference Award.
China's first new chromosome technology — human high-resolution chromosome technology
Human high-resolution chromosome technology, a major scientific and technological achievement at the world advanced level, was successfully researched from 1979 to 1985 by scholars Li Luyun, Xia Jiahui, Dai Heping, Xu Faming, He Xiaoxuan and others at the Genetics Research Office of the former Hunan Medical University. This pioneering achievement not only proved the theoretical and practical application value of high-resolution chromosome technology, but also provided a theoretical basis and technical means for diagnosing and preventing such diseases. Five clinical application cases have been recorded in the world-authoritative work Registry of Human Chromosome Variants and Abnormalities of the Wilmington Medical Center in the United States.
China's first brain and skull diagnostic device — CS14 medium-sized craniocerebral diagnostic instrument
In April 1980, the China Ultrasound Diagnostic Information Center held its founding conference at the Chenzhou Science and Technology Museum. The CS14 medium-sized craniocerebral diagnostic instrument developed by the research institute of the Chenzhou Ultrasound Instrument Factory was invited to be displayed and demonstrated at the conference, and was well received by representatives of experts, professors, and scientific and technological workers engaged in ultrasound diagnosis from 29 provinces, municipalities, and autonomous regions. It was appraised as China's first craniocerebral diagnostic instrument, filling a gap in China's electronic diagnostics. In 1981 it won the Hunan Provincial Major Scientific and Technological Achievement Award. Factory director Chen Yansong was named a national and Hunan Provincial model worker, and the four personnel who participated in developing the diagnostic instrument were awarded the title of outstanding scientific and technological workers.
Hunan's first sterilization technology — fallopian tube silver clip sterilization
In order to find a safe, efficient, simple, economical, and easily reversible fallopian tube sterilization procedure, the Fourth Hospital of Changsha, the Biology Department of Hunan Normal University, and other units successfully developed in 1981 a new sterilization procedure, fallopian tube silver clip sterilization, and first applied it clinically in China, with results reaching the advanced domestic level. The silver clip has a simple structure and possesses locking and anti-slip properties. Using silver clips to block the fallopian tubes, abandoning hand-held thread ligation, can prevent complications such as uneven force, knots tied too tightly cutting through the tube wall and causing fistula, knots too loose leaving the tube unclosed, and vascular clamps crushing the fallopian tube and possibly crushing the tube wall into fistula. In November 1981, relevant experts and professors from some medical colleges and universities across the country unanimously agreed at the appraisal meeting: fallopian tube silver clip sterilization is a safe, efficient, and simple new sterilization procedure, causing little damage to fallopian tube tissue during surgery, with few postoperative complications, a high success rate for reversal, and easy promotion in both urban and rural areas; it was first applied clinically in China, and its results reached the advanced domestic level.
Domestically leading encephalitis treatment method — interferon treatment of Japanese encephalitis and its clinical application
The clinical application of low-dose interferon in treating Japanese encephalitis was researched and completed from 1987 to 1992 by Xie Renhua, Chang Weihong, Yin Meiying, Xie Huangjun and others at the Changsha Infectious Disease Hospital. The research paper "Clinical Observation Report on Interferon Treatment of 51 Cases of Epidemic Japanese Encephalitis" was published in Issue 8 of Intermediate Medical Journal in 1991 and publicly released domestically, attracting attention from the medical and pharmaceutical circles. In August 1991, the Changsha City Science and Technology Commission organized well-known domestic experts for review and technical appraisal, concluding that this research was a treatment method with good efficacy, few side effects, and significantly reduced sequelae and mortality, and was a first in China. Professor Yin Shuzhuang, president of the Pediatric Hospital of Shanghai Medical University, believed that this research was highly scientific and domestically leading. Professor Ouyang Ke of the Infectious Disease Department of Xiangya Hospital believed that this research reached a relatively high academic level.
China's first embryo cryopreservation bank — Hunan Human Frozen Embryo Bank
Human embryo cryopreservation technology was mastered by only a few scientifically and technologically developed countries in the world. In February 1989, Hunan established China's first human frozen embryo bank. In 1987, Lu Guangxiu and others at the Reproductive Engineering Research Office of Hunan Medical University began experiments on frozen storage of mouse embryos, first placing embryos successfully fertilized in test tubes into liquid nitrogen at minus 196 degrees Celsius for long-term storage, then thawing and transplanting them, achieving success. In December 1988, research began on human embryo cryopreservation. In February 1989, China's first human frozen embryo bank was established, successively storing 39 embryos from 19 couples in test tubes with a diameter of just over 1 millimeter, placed in ultra-low-temperature liquid nitrogen tanks with a volume of about 30 liters, to be thawed and revived when needed. This research achievement can provide reproductive insurance for family planning, relieve the worries of couples practicing contraception, provide healthy embryos for couples unsuitable for childbearing to achieve eugenic goals, and at the same time lay the foundation for preimplantation embryo genetics research.
China's first human sperm bank and first artificial insemination baby — frozen semen artificial insemination baby
In 1978, when the first "test-tube baby" was born in the United Kingdom, Lu Huilin, one of the founders of medical genetics in China, was greatly encouraged. He saw hope for gene therapy of genetic diseases and for carrying out positive eugenics, and despite being nearly 80 years old at the time, he resolutely proposed carrying out China's reproductive engineering research and began theoretical preparation and overall design. In 1981, under the leadership of Professor Lu Huilin, the research team overcame numerous difficulties and prejudices, established China's first human frozen sperm bank in 1981, and became the National Sperm Bank Technical Guidance Center. The research team made breakthroughs in artificial insemination technology, using this technology and frozen sperm from the sperm bank for clinical treatment of male infertility and couples in which the male had severe genetic diseases, and in this laboratory China's first frozen semen artificial insemination baby was born. This achievement won the Hunan Provincial Science and Technology Progress Award in 1986. Starting in 1990, they also applied for the first time the technology of separating normal sperm from highly abnormal semen to cases of recurrent miscarriage and stillbirth, and in July 1991 the first normal baby was born, providing a new approach for the application of positive eugenics in China.
The world's first hepatobiliary duct stone lithotripsy technology — micro-explosion lithotripsy for hepatobiliary duct stones
Hepatobiliary duct stones are a common and frequently occurring disease worldwide, and in the 1980s countries around the world competed to research non-laparotomy treatment methods. In 1984, the First Affiliated Hospital of Hunan Medical University responded together with the Changsha Mining Research Institute and the National University of Defense Technology. In October 1987, the project was listed as a research project funded by the National Natural Science Foundation of China, and the research team members Zhang Yangde, Nie Senlin, Zhang Yanggen, Liu Shu, Zhang Shisui, Shen Lirong, Yi Yizhen, Lü Xinsheng, Han Ming and others comprehensively carried out research work. They cooperated closely and conducted multidisciplinary joint tackling of key problems. After hundreds of animal and isolated simulated explosion tests, in August 1988 they conducted the world's first clinical explosion test on human gallstones, achieving success on the first attempt. The broadband signal amplifier pressure measurement device, electric initiation and non-electric initiation micro-exploders they developed, and the new technologies of intracavitary microcatheter-type sensor measurement of micro-explosion pressure and catheter-type micro-exploder directional blasting, were original creations at home and abroad. In September 1990, the technical appraisal organized by the Provincial Science and Technology Commission concluded that this achievement was a world first, and it was listed as one of Hunan's ten major scientific and technological events in 1990, and won the first prize of the 1991 Provincial Science and Technology Progress Award.
The disease virus first discovered by China's medical community — human bocavirus
In August 2006, the Institute for Viral Disease Prevention and Control of the Chinese Center for Disease Control and Prevention and the First People's Hospital of Chenzhou City, Hunan Province, cooperated in using in vitro DNA testing technology to detect human bocavirus (HBoV). This was the first discovery of the existence of this virus by China's medical community. After review by the Fifth Hunan Provincial Medical Science and Technology Award Review Committee, it won the third prize of the 2006 Hunan Provincial Medical Science and Technology Award.
Hunan's world-record-setting lung cancer cryoablation argon-helium cancer treatment technology — 3/4 lung cancer cryotherapy
In November 2007, Cao Peiguo, director of the Oncology Department of the Third Xiangya Hospital of Central South University, successfully set a world record for 3/4 lung cancer cryotherapy and was awarded the World Cryotherapy "Outstanding Contribution Award," becoming the only expert in Hunan so far to win this international medical award. This technology applied the world's most advanced argon-helium medical high technology, introduced it into the field of cancer treatment, and integrated it with the hospital's rich clinical experience accumulated over many years in treating cancer, forming a completely new and unique argon-helium cancer treatment technology.
Hunan's paper winning the highest academic award in neurosurgery — "Analysis of the Mechanism of Chemotherapy Resistance in Brain Tumor Stem Cells"
In July 2008, at the Seventh Asian Congress of Neurological Surgeons, the academic paper "Analysis of the Mechanism of Chemotherapy Resistance in Brain Tumor Stem Cells" read by Professor Fang Jiasheng's research group from Xiangya Hospital of Central South University caused a sensation and received great attention from more than 300 medical experts from more than 20 Asian countries. Because this paper was the first in the world medical community to uncover the mystery of the mechanism of chemotherapy resistance in brain tumor stem cells, it was a major breakthrough in the field of tumor medical research and was awarded the highest academic award of the Asian neurosurgery medical community at the conference — the "KANNO Medical Award."
China's first hypertension gene diagnostic chip — drug treatment gene diagnostic chip
In July 2008, the world's first gene diagnostic chip for hypertension was launched in Hunan. Led by Academician Zhou Honghao of Central South University, the "Series of Products of Gene Diagnostic Chips and Kits for Individualized Drug Therapy," developed over more than 20 years, passed expert acceptance inspection. According to experts, this chip is the world's first gene chip capable of guiding individualized drug therapy for hypertension. After overcoming the challenges of hypertension diagnosis and treatment, the gene diagnostic chip for individualized drug therapy began a general offensive against malignant tumors, diabetes, and other diseases that demand precision in diagnosis and medication.